Abstract: Multi-spot scanning laser, a semiautomated patterned scanning retinal photocoagulator, allows for shorter pulse duration, lower fluence, greater precision than single spot application. Up to 56 (the smallest number being 1) laser spots can be delivered by a single foot pedal depression. And this system has a collection of adjustable predetermined pattern shapes and sizes, including lines, squares, circular arcs, as well as userdefined patterns, and an adjustable “foveal exclusion zone”. Clinically, while treating diabetic retinopathy, panretinal photocoagulation can be accomplished in one or two sessions, and by applying the particular pattern, the macular coagulation can be finished in one foot pedal depression. Moreover, in treatment for retinal vascular diseases, such as central or branch retinal vein occlusion, neovascular glaucoma, Coats disease and so forth, compared with traditional lasers, multispot scanning laser has similar clinical efficacy but less adverse reactions, more patients’ comfort.   (Int Rev Ophthalmol, 2014, 38:   403-409)